Members maintain their ASCLS membership through state and local societies.

Within these constituent societies, members are able to discuss local and statewide problems, compare and contrast issues, standards and methodologies of their respective laboratories, and stimulate local/regional interest in the profession. Constituent state societies produce journals or newsletters to facilitate communications among their members. Workshops and seminars are sponsored to provide continuing education. State societies also sponsor their own annual meetings, usually held in late winter or spring of each year.

State Societies generally maintain local chapters or districts. This national to chapter structure has proven successful in having the Society address the concerns and needs of its members at every level.

As required by the ASCLS Bylaws, an individual must hold membership at the state and national levels. It is this organizational structure that allows for appropriate channeling of local needs to the national level and national activities and programs back to the individual members.

State society dues are used to finance state society activities.